Structure of PDB 7sp8 Chain A Binding Site BS04

Receptor Information
>7sp8 Chain A (length=500) Species: 1278251 (Paramecium bursaria Chlorella virus CZ-2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAVWGISVYGVFVLGFYIAQIVFSEFNRMRLSDWISLRPDNWNATRVAVI
IAGYREDPFMFKKCLESVRDSEYGNVARLICVIDGDEEEDLKMAEIYKQV
YNDNVKKPGVVLCESENKNGSTIDSDVSKNICILQPHRGKRESLYTGFQL
ASMDPSVHAVVLIDSDTVLEKNAILEVVYPLSCDPNIKAVAGECKIWNTD
TILSMLVSWRYFSAFNVERGAQSLWKTVQCVGGPLGAYTIDIINEIKDPW
ITQTFLGNKCTYGDNRRLTNEVLMRGKKIVYTPFAVGWSDSPTNVMRYIV
QQTRWSKSWCREIWYTLGSAWKHGFSGIYLAFECMYQIMYFFLVMYLFSY
IAIKADIRAQTATVLVSTLVTIIKSSYLALRAKNLKAFYFVLYTYVYFFC
MIPARITAMFTMFDARVWLWAKQFLITYMWWAGVLAAGVYSIVDNWYFDW
ADIQYRFALVGICSYLVFVSIVLVIYLIGKITTWNYTPLQKELIEERYLH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7sp8 Chain A Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sp8 Structure, substrate recognition and initiation of hyaluronan synthase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D203 D327
Binding residue
(residue number reindexed from 1)		D166 D290
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0050501 hyaluronan synthase activity
Biological Process
GO:0030213 hyaluronan biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0085029 extracellular matrix assembly
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sp8, PDBe:7sp8, PDBj:7sp8
PDBsum7sp8
PubMed35355017
UniProtM1H2Q1

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