Structure of PDB 7s0t Chain A Binding Site BS04

Receptor Information
>7s0t Chain A (length=1231) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGH
QVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKL
GNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKI
FGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDK
LTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKL
QHRDIHHDFLEKLGKPYVSSARDMINELTMQREYKEPPETKRHVSGHQWQ
SSGEFEAFYKKAQHKTSTIPNFENFIDKQKFSAINTPYEALPQLWPRLPQ
IEAGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFFSNPVDLE
NKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFSSWKYALK
PPTYDAVQKWYNKVPSSVHDSLTHLTLEIHANTRSDKIPDPAIDEVSMII
WCLEEETFPLDLDIAYEGIMIVHKADSTFPTKIQHCINEIPVMFYESEFE
MFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVK
CSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTIESAAFNILHKRL
PHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQLLRKQDYIARNIE
QARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLSPGKKDVRKQKAL
ECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCYSTMIGRVREINL
TENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSVRKSTLSKMLTDI
LDVRVMIKKTMTTLKRLLNNKQLALKLLANVTYGYTSASFSGRMPCSDLA
DSIVQTGRETLEKAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFS
IGHAMAERVTQNNPKPIFLKFEKVYHPSILISKKRYVGFSYESPSQTLPI
FDAKGIETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQI
GKVSAQDFCFAKEVKLGAYKSEKTAPAGAVVVKRRINAEPQYKERIPYLV
VKQLLRCVSPEFLEGLDSEYYINKILIPPLDRLFNLIGINVGNWAQEIKR
STTTLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSY
DCPVFYSRVKAERYLRDNQSVQREEALISLN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7s0t Chain A Residue 1602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s0t Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		D975 F976 D1144
Binding residue
(residue number reindexed from 1)		D772 F773 D934
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7s0t, PDBe:7s0t, PDBj:7s0t
PDBsum7s0t
PubMed35217661
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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