Structure of PDB 7r97 Chain A Binding Site BS04

Receptor Information
>7r97 Chain A (length=226) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNARLEFLGDSILSY
VIANALYHRFPRVDAGDMSRMRATLVRGNTLAELAREFELGECLRLGPGE
LKSGGFRRESILADTVEALIGGVFLDSDIQTVEKLILNWYQTRLDEISPG
DKQKDPKTRLQEYLAGRHLPLPTYLVVQVRGEAHDQEFTIHCQVSGLSEP
VVGTGSSRRKAEQAAAEQALKKLELE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7r97 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r97 Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg 2+ -ion catalysis.
Resolution1.804 Å
Binding residue
(original residue number in PDB)		D45 E117
Binding residue
(residue number reindexed from 1)		D45 E117
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019843 rRNA binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008033 tRNA processing
GO:0010468 regulation of gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r97, PDBe:7r97, PDBj:7r97
PDBsum7r97
PubMed35829618
UniProtP0A7Y0|RNC_ECOLI Ribonuclease 3 (Gene Name=rnc)

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