Structure of PDB 7pxh Chain A Binding Site BS04

Receptor Information
>7pxh Chain A (length=885) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCTFMTEAKDWAGELISG
QTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAF
NIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGL
RFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLL
ENSGDPLDFDNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFF
LLVGLAIFASCIPEIIDLIGTRAKYGGTLKNEKGRRHIVVCGHITYESVS
HFLKDFLHEDREDVDVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGTIMN
PIDLQRVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVI
IQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMM
ANLFAMRSFKTSPDMQSWTNDYLRGTGMEMYTETLSPTFIGIPFAQATEL
CFSKLKLLLLAIEIKSKISINPRGAKIQANTQGFFIAQSADEVKRAWFYC
KAMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPL
IGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNG
SPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMT
FDVYGANVPMITELVNDGNVQFLDQDDDDDPDTELYLTQPFACGTAFAVS
VLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVES
LSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFR
DTSASSKRYVITNPPDDFSLLPTDQVFVLMQFDPG
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain7pxh Chain A Residue 1208 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pxh Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		L53 S274
Binding residue
(residue number reindexed from 1)		L10 S203
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0007623 circadian rhythm
GO:0008582 regulation of synaptic assembly at neuromuscular junction
GO:0009410 response to xenobiotic stimulus
GO:0045433 male courtship behavior, veined wing generated song production
GO:0048512 circadian behavior
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1900074 negative regulation of neuromuscular synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pxh, PDBe:7pxh, PDBj:7pxh
PDBsum7pxh
PubMed34887422
UniProtQ03720|SLO_DROME Calcium-activated potassium channel slowpoke (Gene Name=slo)

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