Structure of PDB 7orm Chain A Binding Site BS04

Receptor Information

>7orm Chain A (length=2145) Species: 11577 (La Crosse virus)

MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHKQEVSKPKILDFDDANMYLASLTMME
QSKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCIS
DFSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVY
SIIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPG
LFLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNS
LAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDI
YLSDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEK
HHVMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLA
DTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKENYEML
RNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFT
FFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDG
KLKVLEQKSEQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINA
DMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDEL
LFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCA
MSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFA
MKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTS
VGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNM
LPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIK
LLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEM
DPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVE
LFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIE
QILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQV
IYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHS
PALVLRAYSKNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMN
EAEKGQRDIVFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFC
SLMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLIT
HFADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLL
FRTGDLRQADLDKYDAMKSHERVTLTITGYNRSITIIGEDNKLTYAELCL
TRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQFVYQIH
SHESITRRNEEHNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSLSRI
KVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNYDNI
RNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFNIYY
SKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEAVVS
LIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPKCFMGNPITRDIN
WVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSKFSEFTKLM

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7orm Chain A Residue 2301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7orm Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): C2064 H2169 D2178 H2182
• Binding residue (residue number reindexed from 1): C1964 H2069 D2078 H2082
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7orm, PDBe:7orm, PDBj:7orm
• PDBsum: 7orm
• PubMed: 35173159
• UniProt: A5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)