Structure of PDB 7m0b Chain A Binding Site BS04

Receptor Information
>7m0b Chain A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINA
LKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVL
ELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLE
RMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHP
DGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRR
HRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTA
VVPGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7m0b Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		V462 Q471 K472 S528 H530
Binding residue
(residue number reindexed from 1)		V227 Q236 K237 S293 H295
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7m0b, PDBe:7m0b, PDBj:7m0b
PDBsum7m0b
PubMed35778389
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

[Back to BioLiP]