Structure of PDB 7lvv Chain A Binding Site BS04

Receptor Information
>7lvv Chain A (length=1011) Species: 980427 (Deinococcus wulumuqiensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLQLVKKFQKRLEDIVAYGGTRNESSVRAAFQQLLSDWAEGSGLRLITEV
TQKAVAGNNVRPDGTLKDSLQQSRGYWESKDEADTLDDEIQKKLAKGYPR
DNIIFEDSRLAVLMQNGEEVQRVDMGDAGALAGLLKLFFEFEPPQVLEFR
KAVDHFKDEMPHLLKILREAADAAEQKADYRGERDHFVEIAKEAINPDFS
PRDAREMLIQHILTGDLFTSVFDNAQYHEDNNIAQQLQQLAATFYKGPVK
RDIAERTKRYYGAIQAAAAQIADHHEKQRFLKALYENFYRAYNPAGAERL
GIFYTPGEIVRFMIEATDTLLEKHFQKELADKGVEILDPATGTGTFITEL
IDFLPKAKLEQKYREELHCNELALLPYYIANLNIEATYAQKMGRYEEFRN
IVLVDTLDNTLFGSVTAENLERAKRQNARPVRVIIGNPPYRANQANENDN
NKNREYKEIDRRIKATYVAASTAQKTKLYDMYSRFLRWATDRLKEDGIVA
FVSNSSFIDSRTFDGFRKEVVKDFDHIYILDMKGNANTSGERRKREGGNV
FNDQIKVGVAVYFLVRSADTKIWYHAVPDFWRAREKLEWLKTTKFEDIEF
DHIRPDAKHNWLGQVDEENDWNEFLPVADKDTKQAKGLGQERAIFKLYSL
GVVTNRDEWVYSRAEDELADKVRYFIGRYNEIIKLPLGDLMSRNWEGDIK
MTRATIADAQSRKSYSLEKNSIVPSLYRPFDVLKMYFSKNLNEMQYQMPS
IFPKGVGENVVIALSGSPAAKPFQVLATDILPSLDLLEKTQCLPFYRYTM
NGERLNNITDYALKAFQTHYADTSISREDIFHYVYAVLHHPAYREKYALN
LRQEFPRIPFYPEFGRWAAWGRELMALHIGFESVAPYPLKRTDEPPKNDT
PEALALAKKARLKVQRDAAKQPTGAVELDGLTTLAGIPAAAWAYKLGNRS
ALEWVLERHKETTPKDATIREKFNTYRFADHKERVIDLLARVTTVSVETV
RIVGEMPAETM
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain7lvv Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lvv Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Y286 L301 F304 A341 G343 T344 F347 E372 L373 D406 T407 P450 F496
Binding residue
(residue number reindexed from 1)		Y285 L300 F303 A340 G342 T343 F346 E371 L372 D405 T406 P439 F485
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lvv, PDBe:7lvv, PDBj:7lvv
PDBsum7lvv
PubMed33826880
UniProtA0A345IJ72

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