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Receptor Information

>7lft Chain A (length=450) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY
VSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIP
TDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVM
YIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW
STLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNA
ARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLK
YLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDY
ICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS
KAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMK

Ligand ID

CPL

InChI

InChI=1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChIKey

JLPULHDHAOZNQI-ZTIMHPMXSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=C(OCC(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COP([O-])(=O)OCC[N+](C)(C)C)CCCCCCCCCCCCCCC
OpenEye OEToolkits 1.5.0	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341	CCCCCCCCCCCCCCCC(=O)OC[CH](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341	CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C/C=C\CCCCC
OpenEye OEToolkits 1.5.0	CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC

Formula

C42 H80 N O8 P

Name

1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;
PALMITOYL-LINOLEOYL PHOSPHATIDYLCHOLINE

PDB chain

7lft Chain A Residue 706 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lft Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	I184 A187 C188 Y267 E269 L272 V317 S320 K323
Binding residue (residue number reindexed from 1)	I29 A32 C33 Y112 E114 L117 V162 S165 K168
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005221	intracellularly cyclic nucleotide-activated monoatomic cation channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

PDB	RCSB:7lft, PDBe:7lft, PDBj:7lft
PDBsum	7lft
PubMed	33651975
UniProt	P29973\|CNGA1_HUMAN Cyclic nucleotide-gated channel alpha-1 (Gene Name=CNGA1)

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Structure of PDB 7lft Chain A Binding Site BS04