Structure of PDB 7ktp Chain A Binding Site BS04

Receptor Information
>7ktp Chain A (length=395) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPLKKCTIE
SIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEQCTPNIDGPNAK
SVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKVEWTGAEESLF
RVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLVYNYQPCDHPDRPCD
STCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECD
PDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKES
VQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKG
NKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ktp Chain A Residue 806 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ktp Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		C561 C567
Binding residue
(residue number reindexed from 1)		C229 C235
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.356: [histone H3]-lysine(27) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0031491 nucleosome binding
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0046976 histone H3K27 methyltransferase activity
GO:0140693 molecular condensate scaffold activity
GO:0140951 histone H3K27 trimethyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0009653 anatomical structure morphogenesis
GO:0021766 hippocampus development
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032259 methylation
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0035098 ESC/E(Z) complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ktp, PDBe:7ktp, PDBj:7ktp
PDBsum7ktp
PubMed33514705
UniProtQ92800|EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (Gene Name=EZH1)

[Back to BioLiP]