Structure of PDB 7k5b Chain A Binding Site BS04

Receptor Information

>7k5b Chain A (length=4453) Species: 5911 (Tetrahymena thermophila)

KYSKRIAWMKTTICDSLQLKDMIVEESFQYEKNKNLLEQFLSGEGLNKIF
AYYQVQEQAQNTTGDLEKIQDKAVWFLRITNPADDKKKASQQDGNDNDII
FGEITPNTVPMLNALMESVYSRQIDHIITEKIQFWGVAEEEQVLEFQQHS
NKFSSEVREAINLDYEAISGLSESEKMQHYEMKFNEWINLISSQLRKDEK
DAGPATELIYWRSRMQKITNWSEQLKSKDFQIVKASLQRHKNHDNQRPRG
DESKLNEAKDNVKYLTTLEKFIPLYNGTPQQIIDTLPALMNAIKMIHTTT
DKMTGLFIKITNQMIKNCKDRILNKMIWEQDPAELIEVLGSCIKLYCEYK
KCYNDTKEKVADMPKGKTSDAQIFGKFDTFVRRLQKLIEIFSNIQQFNAL
LEGMDVLTNKFKKIIDDFKKKGHNLLDTANNKFDRDWVEFNVEISHLDGE
LQNFIDNNFNRFRYSLKLLHKFQSTIKRHNLTSRYNAILHNYATELDTIQ
RVFQDQKSNPPLVRNMPPEAGKIIWARHLFQKITGPINIFPTEIRRYYGS
YNTLGKQLTIYEMWFYQDWVNKIEQSKAALQATLIVRHDENKKLYVNFDL
EIMQLIREAKCLDRQGIEIPESARIILLQEDKFKTYYNELLYALKEYERI
NSKIKPICKNLLLPHIEDLDLKLRPGMVTLTWTSMNIESYLYYVHQGLKK
LEQLIINVNDIIENRIENNLKTVSKVVLVHLPLDSFVQLQEEYINSKTDF
LTSKNVEVERAVDDLLQTIMLYPLDPHVDPVLPEETKRIKRYYFWYFYQA
LLNSTQNSLNAMKYRVFFQVEVQLNGDKVTLNLQEIQKSINRAATAVLRC
SKHLYNWDQATFYDMIACDKEIVKVILLLTGSIQGTKNKVNEFLSGFTKF
EWLCKESIQESIKKFSKNGPTLQNYEDQLKKFSQIEEEIEKIVPTYKIGA
MELMTHNICTSLSTWAKEWKLQYSQDLHKRARQLLDSLTEQTKMLSTKLS
KPVKDIDSLGYVMETLEQIRKEQAEIDMKFNPVQEMYSLLDNYLPGGITD
KDEMDARSLLRRNWDILIQQAEIKGKEYQHKQAIYLKELKQSIKDFTNQV
SIFRRDYEKNGPMERLRRFEDEYDVKYQMYKINARGENLFGLQNQKYPEL
EKTDAEIKNLNKLYNLYDSVIKNIQQFKEKSWQDVSLAKMEEDAGKYGEQ
CSRLPKDLKEWQAYRDLKNYIDSLREQLPLIIPRHWEKIKEITNTKLNYE
NPDQFYIEEIMGAKLDFREDIEDITESADKQLKIRTGLDEINLYWNDMQF
QFGIWGKRMLNGLIVGTILERLEEDQLQLSTFNSQRHVTPFKAEVENLIR
TFSDVNDTLDMWVKVQKLWTSLEPVFTGGDIARQMPLQAKQFQGIDKNWM
KIMEKAVETKKVIPCCQNDMLKDFLPDLNRKLEDCQKMLEAYLEGKRKKF
PRFYFVSNPTLLKILSQGSEPTSIQEDFEKLFDAITKVTFESAKDKKNPA
LKQITQIQQVIGRNEENISLTGYYVKCEGNIEDWLKKLEQNMQQTLKDIA
SAAAQQVFQVGLKEFVSSQASQIALLGLQILWTSKVNEGLERLSRNERNA
MDIKRNEIKEHMNILSSMCLEDLNGAVERTKVETLVTIQVHQKDISMDLK
CKDVNDFEWQKQTRIAWKTDIDECIISITDWDSPYSYEFLGAKERLCITP
LTDRCYITLAQAMSMYYGGAPAGPAGTGKTETVKDLGRTLGVFVVVTNCS
DQHRYRDMAKIFKGLVQSGLWGCFDEFNRIDLEVLSVVAMQVESITTARK
QHMKKFMFPEEEIEIELIPTVSYFITMNPGYAGRQELPENLKVLFRGVSM
MVPDREIIIKVKLASVGYLQIDLLAKKFNVLYRLCEEQLSKQRHYDFGLR
NILSVLRTAGNTKRQEIKSDEEMLLMRSLRDMNLSKLVADDIPLFNGLLA
DIFPKLKEVPKKLYPDVEKKIPEEINAESYLINTPSFQLKIIQLYETCLV
RHGFMLVGPTGSGKSTIMKILTEVLTKLGSPHKIVIMNPKAITAEQMYGV
KSEISDDWIPGVFSTIWAKSNNRALKHTTWITCDGPVDAIWIENLNTVLD
DNKILTLANGERIAMTENCKVVFEVENLNNASPATVSRCGQVYVSPTDLG
YEAVIEGWIRNRKASGRAEESDKLGNILRKYLINMRFIELQSKECKEPMM
DTSPVISVINILNLLTGCLQYFVQTQRTLSEQEYEKFIVYSMAWAIGGIY
EAQDRVRFHELLLAKNAPIPQKGKENETVFDYYVSQDYLDWKICSPEEWV
PPQSLQFSQLLLPTLDSFRAEMLLNFILTQPKSHTCSNSALLIGGSGTAK
TSSVLLYCNKFDPQKMLFKRTNFSSATSPFMFQSTIEAECDFKVGKEFAP
PGNKMMTIFIDDMSMPFVNKWGDQITLELVRQLIETGGFYMLDKTQRGNQ
RKMKNLQYIGAMNHPGGGRNDIPNRLKRQFFIFNMILPLSIEGIYGPIIK
HMFKQKYFSDSTYKVIESLTSATIALWNKVKSTMLPTPAKFHYVFNMREL
SRIFKGILTCKKDTINDAPKSMKIKPELFLVGLWRHEAERVLADKLVNNK
DKDTVMGYIQEVSLESFSQIENEILEKYSSEKTFLFCDFLRPDVINEDGI
IEEEAPKIYEAIDSLTELRKRCNFLLSFYNDRNPSKKMPLVLFDDALKHL
LRISRIIRQPRSSGLLVGVGGSGKQSLTRLAGFIGKNLIQQIIVTKTYSD
KDLKEDIKKGFDDAGHLGKQVTFLMTDSEVKKEEFLEYINMVLSTGEIPN
LLAKDEREVWLGDISQAYCKEKNLGNIDPPQSELWTYFVDRVRDNFHIML
CFSPVGQKFRERARKFPALFNECTIDWFLPWPEEALVSVAETFIKNFDKL
DTKEETKQELMKHMGNVHLMVNEICDEYYQKMRRQVYVTPKSFLSYLNSY
KTLYIEKYDELDQQEESFKIGLNKIQEATITINQMEISLKEEEIQLNEAT
EKTNQLLANLDKESKKANQKGEEVAATNKQCEIQAEQISKEKEEAERELE
AALPALRRAQEAVDSIESKDIVELKANKKPLDIIKYIMNAVLVFFKARLI
PIQIEERVFNKKEGKAVLFLKESYDESGIQTLGDMNFMKKLKEFEKDSIN
EETIELLEPYLNQSEDWFNDTFATKASKAAAGILKWAFAIYEYHQKSKIV
KPKRIQVAIAEGRQAIALKELEKAREDLAQIQAYIKNLKDVYTKQMEEKN
ELEMKAAKTKKKINTARTLITSLSGEKDRWGKGAQDISDQKRKLVGNVSL
STAFISYCGPFNAEYRNKLAQQRFVVDMKKRGVPVTPGLELTSFLIDDAT
IGEWNLQGLPKDDLSIQNGIMVTNSARYPLFIDPQGQGQNWIRNKLSASI
IPERCITTLSHPKFKDMFLKYCMESGLTLIVENIENEVDPMMDPVLERQI
IVKGKTQFVNVAGTEMELSKEFKLFMTCRLANPSFSPELSAKTTIIDFTV
TQSGLEQQLLGKVISKEQKALEDSLNQLLADVNQNQKDLQRLDKNLLERL
INSQGNLLDDTELMDVLNNTKTQAKEVAAKLIDAEIKTKEINEKREQYRP
VAIRGSAIYFTMIEVSLVNWMYNSSLEQFLKLFIESIDLSEKAQLPSNRV
KNIISFLTFHVYRYVNRGLFEKDKITFILMMAFKILTTAGTISSGDVSLF
LKSGDALDIKSERQKQISYLEDNQWLNILALSKHTFSGQTLPFFKELPDL
ISRSENQWRNWIDKNDPENFPIPDFAESINQEKEIGSFISLCLVRSLRND
RTLIATQNFISNVLGKEFTDPISYPIEGIWQESSNMDPVLFLLSAGADPT
SSIDELAKKKKKFPCEKVSMGEGQERVARQVIMKGFVEGGWVILQNCHLG
LKFMEEIETLVSPINQIHEDFRLWITCEQHPKFPLGLLQKTLKVTNEPPK
GLKAGLYKTFTTIITQEFIDKVDHSNWRSLIFTICFLHSIVIERKKFGPL
GWCVPYEYNYSDLEASLLYIEKYLTNLMSTPHNLPISMNVVRYMICEVQY
GGRITDDLDRELFITYGETYLKDGIFGNDYFFYDIMVDQKFKYRIPQNPS
AELIKYQEYIAKVPTVDNPEVFGLHSNADLTFRLKESKEMINTVMETRPK
DSSVGGGKTREEIVQDKAKDMLKNLPPDYNDVEVRELVSKLGGPNPKTST
ERGMTVPLNIFLYQEVTRMQRVIGLVRKTLQDTILAIDGQIIMTPEILEA
INAIYDAKVPNSWLYDPSGAEISWLLPNLGSWSTSLSDRNKQLNDWLRSG
QRPILFWLTGFFNPQGFLTGMKQEVTRNHKGKGGEAWSLDDVVYSTTVKE
REKEKDIEQPPAEGVYIKGLYLEGCKWSKNGLDDSDPKKIFADLPILHVS
AINKKMSNTYLCPVYKYPKRTDKYLIFRVGLPCEGSNNPSHWKLRGVALL
CST

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7k5b Chain A Residue 5001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7k5b Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
• Resolution: 4.5 Å
• Binding residue (original residue number in PDB): S2164 R2627
• Binding residue (residue number reindexed from 1): S2015 R2478
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008569 minus-end-directed microtubule motor activity
• GO:0016887 ATP hydrolysis activity
• GO:0045505 dynein intermediate chain binding
• GO:0051959 dynein light intermediate chain binding

Biological Process

• GO:0007018 microtubule-based movement

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005858 axonemal dynein complex
• GO:0005874 microtubule
• GO:0005929 cilium
• GO:0030286 dynein complex

External links

• PDB: RCSB:7k5b, PDBe:7k5b, PDBj:7k5b
• PDBsum: 7k5b
• PubMed: 34556869
• UniProt: Q22A67