Structure of PDB 7jm6 Chain A Binding Site BS04

Receptor Information
>7jm6 Chain A (length=667) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSLKYESLDYDNSENQLFLEEERRINHAAFRTVEIKRWVICAMIGILTGL
VACFIDIVVENLAGLKYRVVKDNIDKFTEKGGLSFSLLLWATLNASVVMV
GSVIVAFIEPVAAGSGIPQIKCYLNGVKIPHVVRLKTLVIKVCGVILSVV
GGLAVGKEGPMIHSGAVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFV
SAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLN
SVLSVYHGNAWDLSSPGLINFGRFDSEKMGYTIQEIPIFIFMGVVGGILG
ALFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTAAVGFVMIYCSRAFF
NTPEKSVVNLFHDPPGSYNPMTLGMFTLMYFFLACWTYGLTVSAGVFIPS
LLIGAAWGRLFGISLSYLSKGSIWADPGKYALMGAAAQLGGIVRMTLSLT
VIMMEATGNVTYGFPIMLVLMTAKIVGDYFVEGLYDMHIQLQSVPFLHWE
APVTSHSLTAREVMSTPVTCLRRIERVGTVVDILSDTSSNHNGFPVVESN
PNTTQVAGLRGLILRSQLIVLLKHKVFVERRLKLKDFRDAYPRFPPIQSI
HVSQDERECMIDLSEFMNPSPYTVPREASLPRVFKLFRALGLRHLVVVNN
HNEVVGMVTRKDLARYR
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7jm6 Chain A Residue 905 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jm6 Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		G198 G200 Q203
Binding residue
(residue number reindexed from 1)		G114 G116 Q119
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jm6, PDBe:7jm6, PDBj:7jm6
PDBsum7jm6
PubMed32749217
UniProtQ5ZL60

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