Structure of PDB 7e1z Chain A Binding Site BS04

Receptor Information
>7e1z Chain A (length=976) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEW
IKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAV
VIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGD
LVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLET
RNIAFFSTNCVEGTARGIVVYTGDRTVMGRIAGQTPIAAEIEHFIHIITG
VAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLT
AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQI
HEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAV
AGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPN
TSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGG
LGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRA
AVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAAR
LNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQ
KLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD
MILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIAN
IPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNE
RLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWIND
VEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQ
GMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLL
IFVYDEVRKLIIRRRPGGWVEKETYY
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7e1z Chain A Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7e1z Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K726 A745 A746 D747
Binding residue
(residue number reindexed from 1)		K679 A698 A699 D700
Annotation score5
Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016791 phosphatase activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051087 protein-folding chaperone binding
GO:1990239 steroid hormone binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002028 regulation of sodium ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0007231 osmosensory signaling pathway
GO:0008217 regulation of blood pressure
GO:0009410 response to xenobiotic stimulus
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0031947 negative regulation of glucocorticoid biosynthetic process
GO:0034220 monoatomic ion transmembrane transport
GO:0036376 sodium ion export across plasma membrane
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045989 positive regulation of striated muscle contraction
GO:0055078 sodium ion homeostasis
GO:0055119 relaxation of cardiac muscle
GO:0060047 heart contraction
GO:0071383 cellular response to steroid hormone stimulus
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086009 membrane repolarization
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:1902600 proton transmembrane transport
GO:1903416 response to glycoside
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030315 T-tubule
GO:0030424 axon
GO:0031090 organelle membrane
GO:0032991 protein-containing complex
GO:0036126 sperm flagellum
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection
GO:0045121 membrane raft
GO:0060342 photoreceptor inner segment membrane
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e1z, PDBe:7e1z, PDBj:7e1z
PDBsum7e1z
PubMed35803952
UniProtP05023|AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1 (Gene Name=ATP1A1)

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