Structure of PDB 7c45 Chain A Binding Site BS04

Receptor Information
>7c45 Chain A (length=295) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SATSSSSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAK
QLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFD
CRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVA
GLTRDSAVQTAMTLRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKD
VPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGG
CHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7c45 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7c45 Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
Resolution1.769 Å
Binding residue
(original residue number in PDB)		D80 E82 D230
Binding residue
(residue number reindexed from 1)		D39 E41 D184
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7c45, PDBe:7c45, PDBj:7c45
PDBsum7c45
PubMed33332555
UniProtQ38DE2

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