Structure of PDB 7at8 Chain A Binding Site BS04

Receptor Information
>7at8 Chain A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WSPLQQNFMVEGTFIEELIKNYDLFCRRCFKYDCFLHPEASMFRVLIGTY
YDNFCAIARLIRQVYEFRVKESAAAAAAAAAAAAANHVYNYQPCDHPRQP
CDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRE
CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIK
DPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATR
KGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS
QADALKYVGIE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7at8 Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7at8 Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		C541 C554 C561 C565
Binding residue
(residue number reindexed from 1)		C94 C107 C114 C118
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.356: [histone H3]-lysine(27) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
GO:0046976 histone H3K27 methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7at8, PDBe:7at8, PDBj:7at8
PDBsum7at8
PubMed33211010
UniProtQ15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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