Structure of PDB 6xnz Chain A Binding Site BS04

Receptor Information
>6xnz Chain A (length=550) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEK
VLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPVDTIAKRFR
YDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCDGMGDVSEK
HGSGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEPKPNSVLCCKPLCLM
LADESDHETLTAILSPLIAEREAMKSSELTLEMGGIPRTFKFIFRGTGYD
EKLVREVEGLEASGSVYICTLCDTTRLEASQNLVFHSITRSHAENLQRYE
VWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIF
QLEIGEVYKHPNASKEERKRWQATLDKHLRKRMNLKPIMMMNGNFARKLM
TQETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQ
YSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWAS
EGNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6xnz Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		S477 C478 S479 Q480 K483 M974 N975 A976 R977 Q978 D986 K989
Binding residue
(residue number reindexed from 1)		S19 C20 S21 Q22 K25 M516 N517 A518 R519 Q520 D528 K531
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0033151 V(D)J recombination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6xnz, PDBe:6xnz, PDBj:6xnz
PDBsum6xnz
PubMed32945578
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

[Back to BioLiP]