Structure of PDB 6tz2 Chain A Binding Site BS04

Receptor Information
>6tz2 Chain A (length=1208) Species: 110829 (Bombyx mori cypovirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TELYNTIFSETRKFTRESFKEIEHLTAKLANDRVARHDFLFNNSIALISD
YSGEDSNGNQLQATVTIPNEITNPKEYDPSDYPLAEDESFFKQGHKYDYL
VTFRAGSLTNTYEPKTKMYKLHAALDKLMHVKQRKSRFADLWRELCAVIA
SLDVWYQTTNYPLRTYVKLLFHKGDEFPFYESPSQDKIIFNDKSVASILP
TFVYTCCQVGTAIMSGILTHVESIVAMNHFLHCAKDSYIDEKLKIKGIGR
SWYQEALHNVGRATVPVWSQFNEVIGHRTKTTSEPHFVSSTFISLRAKRA
ELLYPEFNEYINRALRLSKTQNDVANYYAACRAMTNDGTFLATLTELSLD
AAVFPRIEQRLVTRPAVLMSNTRHESLKQKYANGVGSIAQSYLSSFTDEI
AKRVNGIHHDEAWLNFLTTSSPGRKLTEIEKLEVGGDVAAWSNSRIVMQA
VFAREYRTPERIFKSLKAPIKLVERQQSDRRQRAISGLDNDRLFLSFMPY
TIGKQIYDLNDNAAQGKQAGNAFDIGEMLYWTSQRNVLLSSIDVAGMDAS
VTTNTKDIYNTFVLDVASKCTVPRFGPYYAKNMEVFEVGKRQSQVKYVNA
AWQACALEAANSQTSTSYESEIFGQVKNAEGTYPSGRADTSTHHTVLLQG
LVRGNELKRASDGKNSCLTTIKILGDDIMEIFQGNENDTHDHAVSNASIL
NESGFATTAELSQNSIVLLQQLVVNGTFWGFADRISLWTREDTKDIGRLN
LAMMELNALIDDLLFRVRRPEGLKMLGFFCGAICLRRFTLSVDNKLYDST
YNNLSKYMTLVKYDKNPDFDSTLMSLILPLAWLFMPRGGEYPAYPFERRD
GTFTEDESMFTARGAYKRRLLYDVSNIREMIQQNSMVLDDDLLHEYGFTG
ALLLIDLNILDLIDEVKKEDISPVKVNELATSLEQLGKLGEREKSRRAAS
DLKIRGHALSNDIVYGYGLQEKIQKSAMATKETTVQSKRVSSRLHEVIVA
KTRDYKIPTMPADALHLYEFEVEDVTVDLLPHAKHTSYSNLAYNMSFGSD
GWFAFALLGGLDRSANLLRLDVASIRGNYHKFSYDDPVFKQGYKIYKSDA
TLLNDFFVAISAGPKEQGILLRAFAYYSLYGNVEYHYVLSPRQLFFLSDN
PVSAERLVRIPPSYYVSTQCRALYNIFSYLHILRSITSNQGKRLGMVLHP
GLIAYVRG
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain6tz2 Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6tz2 Conservative transcription in three steps visualized in a double-stranded RNA virus.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R37 D144 R147 Y184 N195 R791
Binding residue
(residue number reindexed from 1)		R33 D140 R143 Y180 N191 R787
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6tz2, PDBe:6tz2, PDBj:6tz2
PDBsum6tz2
PubMed31695188
UniProtQ993A4

[Back to BioLiP]