Structure of PDB 6tw1 Chain A Binding Site BS04

Receptor Information
>6tw1 Chain A (length=703) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENMLKHRFEIIEGQERNIAWTIVNSICNMTENSKPRF
LPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDGEEM
ATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEEEEFSYPPTF
QRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFD
PRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACL
DTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHL
KWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASE
LTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYIN
TALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTD
VVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVR
TNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRE
NDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLL
LLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQL
SMG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6tw1 Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6tw1 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H41 D108 E119 I120
Binding residue
(residue number reindexed from 1)		H41 D103 E114 I115
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting

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Molecular Function
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Biological Process
External links
PDB RCSB:6tw1, PDBe:6tw1, PDBj:6tw1
PDBsum6tw1
PubMed32304664
UniProtH6QM92

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