Structure of PDB 6tax Chain A Binding Site BS04

Receptor Information

>6tax Chain A (length=4416) Species: 10090 (Mus musculus)

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAKLTLGLSILFMVEAAEFTVPKKDLDSLCYLLIP
SAGSPEALHSDLSPVLRIRQRWRIYLTNLCLRCIDERCDRWLGILPLLHT
CMQKSPPKKNSKSQPEDTWAGLEGISFSEFRDKAPTRSQPLQFMQSKMAL
LRVDEYLFRSWLSVVPLESLSSYLENSIDYLSDVPVRVLDCLQGISYRLP
GLRKISNQNMKKDVENVFKMLMHLVDIYQHRIFGENLLQIYLTECLTLHE
TVCNITANHQFFEIPALSAELICKLLELSPPGEKSYEDLVTSTLQEALAT
TRNWLRSLFKSRMLSISSAYVRLTYSEEMAVWRRLVEIGFPEKHGWKGSL
LGDMEGRLKQEPPRLQISFFCSSQCRDGGLHDSVSRSFEKCVIEAVSSAC
QSQTSVLEGLSCQDLQKFGTLLSAVITKSWPVHNGEPVFDVDEIFKYLLK
WPDVRQLFELCGTNEKIIDNITEEGRQLMATAESVFQKVAGELENGTIVV
GQLELILEHQSQFLDIWNLNRRRDVRSLLKRRRDDLLFLKQEKRYVESLL
RQLGRVKHLVQVDFGNIEIIHSQDLSNKKLNEAVIKLSYKRETHYCLSPD
IREMASKLDSLKDSHIFQDFWQETAESLNELKVSLPEVLEYLYNPCYDNF
YTLYENLKSGKITFAEVDAIFKDFVDKYDELKNDLKFMCTMNPQDQKGWI
SERVGQIKEYHTLHQAVSSAKVILQVRRALGVTGDFSVLNPLLNFADSFE
DFGNESPQFIKAKQLLQDISEPRQRCLEELARQTELVAWLHKALEDINEL
KVFVDLASISAGENDIDVDRVACFHDAVQGYASLLYKMDERTNFSDFMNH
LQELWRALDNDQHLPDKLKDSARNLEWLKTVKESHGSVELSSLSLATAIN
SRGVYVIEAPKDGQKISPDTVLRLLLPDPEALRTYSTEELKELLNKLMLM
SGKKDHNSNTEVEKFSEVFSNMQRLVHVFIKLHCAGNMLFRTWTAKVYCC
PDGGIFMNFGLELLSQLTEKGDVIQLLGALCRQMEDFLDNWKTVVAQKRA
EHFYLNFYTAEQLVYLSSELRKPRPSEAALMMLSFIKGKCTVQDLVQATS
ACESKADRYCLREVMKKLPQQLLSEPSLMGKLQVIMMQSLVYMSAFLPHC
LDLDALGRCLAHLATMGGTPVERPLPKGLQAGQPNLILCGHSEVLPAALA
IYMQAPRQPLPTFDEVLLCTPATTIEEVELLLRRCLTSGSQGHKVYSLLF
ADQLSYEVGCQAEEFFQSLCTRAHREDYQLVILCDAAREHCYIPSTFSQY
KVPLVPQAPLPNIQAYLQSHYQVPKRLLSAATVFRDGLCVGIVTSERAGV
GKSLYVNTLHTKLKAKLRDETVPLKIIRLTEPHLDENQVLSALLPFLKEK
YQKMPVIFHIDISTSVQTGIPIFLFKLLILQYLMDINGKIWRRSPGHLYL
VEIPQPLFKFLDLFPKVTCRPPKEVIDMEPAMDPVEFCSEAFQRPYQYLK
RFHQQQNLDTFQYEKGSVEGSPEECLQHFLIYCGLINPSWSELRNFAWFL
NCQLKDCEASIFCKSAFTGDTLRGFKNFVVTFMILMARDFATPTEEDLAP
FSLRKRWESEPHPYVFFNGDHMTMTFIGFHLETNNNGYVDAINPSNGKVI
KKDVMTKELFDGLRLQRVPFNIDFDNLPRYEKLERLCLALGIEWPIDPDE
TYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLKRGSV
EAETMKLVKVHGGTTPSMIYSKVKEAERTAFSNKAQHKLDTILFFDEANT
TEAVSCIKEILCDRTVDGEHLHEDSGLHIIAACNPYRKHSQEMILRLESA
GLGYRVSAEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEK
LYIQQIVQRLVDSVSVNPSETCVIADVLSASQMFMRKRENECGFVSLRDV
ERCVKVFRWFHDHSDMLLKELDKFLHESSDSTHTFERDPVLWSLVMAIGV
CYHASLEEKASYRTAIARCFPKPYNSSRAILDEVTHVQDLFLRGAPIRTN
IARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKIIVADAMQGQAA
FSELFRCLKQVHLVSFQCSPHSTPQGIISTFKQCARFQQGKDLGQYVSVV
VLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPYKKVGFVGISNWALDP
AKMNRGIFVSRGSPNEKELIESAEGICSSDRLVQDKIRGYFAPFAKAYET
VCQKQDKEFFGLRDYYSLIKMVFAKAKASKRGLSPQDITHAVLRNFSGKD
NIQALSIFTASLPEARYKEEVSTVELIKQNIYPGPGAESRYLLVLTRNYV
ALQILQQTFFEGQQPEIIFGSSFPQDQEYTQICRNINRVKICMETGKMVV
LLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHTAFRLIVI
EEKDVVYKQFPVPLINRLEKHYLDMNTVLQPWQKSIVQELQQWAHEFADV
KADQFIARHKYSPADVFIGYHSDACASVVLQAVERQGCRDLTEELYRKVS
EEARSILLDCATPDAVVRLSGSSLGSFTAKQLSQEYYYAQQHNSFVDFLQ
AHLRMTHHECRAVFTEITTFSRLLTGNDCDVLASELRGLASKPVVLSLQQ
YDTEYSFLKDVRSWLTNPGKRKVLVIQADFDDGTRSAQLVASAKYTAINE
INKTQGTKDFVFVYFVTKLSRMGSGTSYVGFHGGLWRSVHIDDLRRSTIM
ASDVTKLQNVTISQLFKPESQFLDTTRLVQSCVQGAVGMLRDQNESCARN
MRRVTILLDLLNEDNTRNASFLRESKMRLHVLLNKQEENQVRSLKEWVTR
EAANQDALQEAGTFRHTLWKRVQDVVTPILASMIAHIDRDGNLELLAQPD
SPAWVQDLWMFIYSDIKFLNISLVSFILVQSHMNLLKDAYNAVPFSWRIR
DYLEELWVQAQYITDTEGLSKKFVEIFQKTPLGVFLAQFPVAQQQKLLQS
YLKDFLLLTMKVSSREELMFLQMALWSCLRELQEASGTPDETYKFPLSLP
WVHLAFQHFRTRLQNFSRILTIHPQVLSSLSQAAEKHSLAGCEMTLDAFA
AMACAEMLKGDLLKPSPKAWLQLVKNLSTPLELVCSEGYLCDSGSMTRSV
IQEVRALWNRIFSIALFVEHVLLGTESHIPELSPLVTTYVSLLDKCLEED
SNLKTCRPFVAVMTTLCDCKDKASKKFSRFGIQPCFICHGDAQDPVCLPC
DHVYCLRCIQTWLIPGQMMCPYCLTDLPDKFSPTVSQDHRKAIEKHAQFR
HMCNSFFVDLVSTMCFKDNTPPEKSVIDTLLSLLFVQKELLHREHTKSLS
PFDDVVDQTPVIRSVLLKLLLKYSFHEVKDYIQNYLTQLEKKAFLTEDKT
ELYLLFISCLEDSVHQKTSAGCRNLEQVLREEGHFLRTYSPGLQGQEPVR
IASVEYLQEVARVRLCLDLAADFLSELQEGSELAEDKRRFLKHVEEFCTR
VNNDWHRVYLVRKLSSQRGMEFVQSFSKQGHPCQWVFPRKVIAQQKDHVS
LMDRYLVHGNEYKAVRDATAKAVLECKTLDIGNALMACRSPKPQQTAYLL
LALYTEVAALYRSPNGSLHPEAKQLEAVNKFIKESKILSDPNIRCFARSL
VDNTLPLLKIRSANSILKGTVTEMAVHVATILLCGHNQILKPLRNLAFYP
VNMANAFLPTMPEDTQTGHVLGSPQSSGVAEVSDRGQSPVVFILTRLLTH
LAMLVGATHNPQALTVIIKPWVQDPQGFLQQHIQRDLEQLTKMLGRSADE
TIHVVHLILSSLLRVQSHGVLNFNAELSTKGCRNNWEKHFETLLLRELKH
LDKNLPAINALISQDERISSNPVTKIIYGDPATFLPHLPQKSIIHCSKIW
SCRRKITVEYLQHIVEQKNGKETVPVLWHFLQKEAELRLVKFLPEILALQ
RDLVKQFQNVSRVEYSSIRGFIHSHSSDGLRKLLHDRITIFLSTWNALRR
SLETNGEIKLPKDYCCSDLDLDAEFEVILPRRQGLGLCGTALVSYLISLH
NNMVYTVQKFSNEDNSYSVDISEVADLHVISYEVERDLNPLILSNCQYQV
QQGGETSQEFDLEKIQRQISSRFLQGKPRLTLKGIPTLVYRRDWNYEHLF
MDIKNKMAQSSLPNLAISTISGQLQSYSDACEALSIIEITLGFLSTAGGD
PGMDLNVYIEEVLRMCDQTAQVLKAFSRCQLRHIIALWQFLSAHKSEQRL
RLNKELFREIDVQYKEELSTQHQRLLGTFLNEAGLDAFLLELHEMIVLKL
KGPRAANSFNPNWSLKDTLVSYMETKDSDILSEVESQFPEEILMSSCISV
WKIAATRKWDRQSRGG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6tax Chain A Residue 5204

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tax Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): C3947 C3950 C3967 C3970
• Binding residue (residue number reindexed from 1): C3285 C3288 C3305 C3308
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.2.-
  2.3.2.27: RING-type E3 ubiquitin transferase.
  3.6.4.-

Gene Ontology

Molecular Function

• GO:0004842 ubiquitin-protein transferase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:6tax, PDBe:6tax, PDBj:6tax
• PDBsum: 6tax
• PubMed: 32573437
• UniProt: E9Q555|RN213_MOUSE E3 ubiquitin-protein ligase RNF213 (Gene Name=Rnf213)