Structure of PDB 6t16 Chain A Binding Site BS04

Receptor Information
>6t16 Chain A (length=1275) Species: 1245 (Leuconostoc mesenteroides) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDPITGGHYENHNGYFVYIDASGKQVTGLQNIDGNLQYFDDNGYQVKGSF
RDVNGKHIYFDSVTGKASSNVDIVNGKAQGYDAQGNQLKKSYVADSSGQT
YYFDGNGQPLIGLQTIDGNLQYFNQQGVQIKGGFQDVNNKRIYFAPNTGN
AVANTEIINGKLQGRDANGNQVKNAFSKDVAGNTFYFDANGVMLTGLQTI
SGKTYYLDEQGHLRKNYAGTFNNQFMYFDADTGAGKTAIEYQFDQGLVSQ
SNENTPHNAAKSYDKSSFENVDGYLTADTWYRPTDILKNGDTWTASTETD
MRPLLMTWWPDKQTQANYLNFMSSKGLGITTTYTAATSQKTLNDAAFVIQ
TAIEQQISLKKSTEWLRDAIDSFVKTQANWNKQTEDEAFDGLQWLQGGFL
AYQDDSHRTPNTDSGNNRKLGRQPINIDGSKDTTDGKGSEFLLANDIDNS
NPIVQAEQLNWLHYLMNFGSITGNNDNANFDGIRVDAVDNVDADLLKIAG
DYFKALYGTDKSDANANKHLSILEDWNGKDPQYVNQQGNAQLTMDYTVTS
QFGNSLTHGANNRSNMWYFLDTGYYLNGDLNKKIVDKNRPNSGTLVNRIA
NSGDTKVIPNYSFVRAHDYDAQDPIRKAMIDHGIIKNMQDTFTFDQLAQG
MEFYYKDQENPSGFKKYNDYNLPSAYAMLLTNKDTVPRVYYGDMYLEGGQ
YMEKGTIYNPVISALLKARIKYVSGGQTMATDSSGKDLKDGETDLLTSVR
FGKGIMTSDQTTTQDNSQDYKNQGIGVIVGNNPDLKLNNDKTITLHMGKA
HKNQLYRALVLSNDSGIDVYDSDDKAPTLRTNDNGDLIFHKTNTFVKQDG
TIINYEMKGSLNALISGYLGVWVPVGASDSQDARTVATESSSSNDGSVFH
SNAALDSNVIYEGFSNFQAMPTSPEQSTNVVIATKANLFKELGITSFELA
PQYRSSGDTNYGGMSFLDSFLNNGYAFTDRYDLGFNKADGNPNPTKYGTD
QDLRNAIEALHKNGMQAIADWVPDQIYALPGKEVVTATRVDERGNQLKDT
DFVNLLYVANTKSSGVDYQAKYGGEFLDKLREEYPSLFKQNQVSTGQPID
ASTKIKQWSAKYMNGTNILHRGAYYVLKDWATNQYFNIAKTNEVFLPLQL
QNKDAQTGFISDASGVKYYSISGYQAKDTFIEDGNGNWYYFDKDGYMVRS
QQGENPIRTVETSVNTRNGNYYFMPNGVELRKGFGTDNSGNVYYFDDQGK
MVRDKYINDDANNFYHLNVDGTMSR
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain6t16 Chain A Residue 1508 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t16 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T249 K280
Binding residue
(residue number reindexed from 1)		T100 K131
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.5: dextransucrase.
Gene Ontology
Molecular Function
GO:0046527 glucosyltransferase activity
Biological Process
GO:0009250 glucan biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6t16, PDBe:6t16, PDBj:6t16
PDBsum6t16
PubMed32409580
UniProtQ9RE05

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