Structure of PDB 6sc6 Chain A Binding Site BS04

Receptor Information

>6sc6 Chain A (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPA
CGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKF
LWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQN
WKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQ
FCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLL
QDNNVMFNTEPPGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEY
LVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQ
KLTEEVPLGQSIPRR

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6sc6 Chain A Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6sc6 Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases.
Resolution	2.25 Å
Binding residue (original residue number in PDB)	C825 C828 H836 C841
Binding residue (residue number reindexed from 1)	C129 C132 H140 C145
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.31: RBR-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding

	Cellular Component
GO:0071797	LUBAC complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6sc6, PDBe:6sc6, PDBj:6sc6
PDBsum	6sc6
PubMed	31813847
UniProt	Q96EP0\|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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