Structure of PDB 6rbi Chain A Binding Site BS04
Receptor Information
>6rbi Chain A (length=454) Species:
9606
(Homo sapiens) [
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MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPF
ACDVDKLHFTPRIQRLNELEAQTRVKLRDYTLRTFGEMADAFKSDYFNMP
VHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDKLSPE
EEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHI
EDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLH
QLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVAST
VQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCF
MSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKL
RAES
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
6rbi Chain A Residue 809 [
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Receptor-Ligand Complex Structure
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PDB
6rbi
Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol
Resolution
2.21 Å
Binding residue
(original residue number in PDB)
C706 C708 C723 C725
Binding residue
(residue number reindexed from 1)
C406 C408 C423 C425
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
G481 Y488 H499 E501 H587 A599
Catalytic site (residue number reindexed from 1)
G181 Y188 H199 E201 H287 A299
Enzyme Commision number
1.14.11.67
: [histone H3]-trimethyl-L-lysine(4) demethylase.
External links
PDB
RCSB:6rbi
,
PDBe:6rbi
,
PDBj:6rbi
PDBsum
6rbi
PubMed
UniProt
Q9UGL1
|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)
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