Structure of PDB 6qzj Chain A Binding Site BS04

Receptor Information
>6qzj Chain A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVH
VAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSL
FYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQ
LCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPP
RIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGS
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain6qzj Chain A Residue 511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qzj Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F74 G222 Y223 A224 R229
Binding residue
(residue number reindexed from 1)		F41 G189 Y190 A191 R196
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015267 channel activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzj, PDBe:6qzj, PDBj:6qzj
PDBsum6qzj
PubMed31831212
UniProtO14520|AQP7_HUMAN Aquaporin-7 (Gene Name=AQP7)

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