Structure of PDB 6qig Chain A Binding Site BS04

Receptor Information
>6qig Chain A (length=581) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHL
VKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYI
TRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHQIGH
SFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGR
ARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREH
LDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELT
PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADL
QAEMCNTQACEKTQLEFMSQQCARTHWGAAVPHSQGDALCRHMCRARGDS
FLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGD
NSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG
RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE
DADIQVYRRYGEEYGNLTRPDITFTYFQPKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6qig Chain A Residue 719 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qig Crystal structure and substrate-induced activation of ADAMTS13.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E83 D166
Binding residue
(residue number reindexed from 1)		E5 D88
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.87: ADAMTS13 endopeptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0030198 extracellular matrix organization

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Molecular Function
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Biological Process
External links
PDB RCSB:6qig, PDBe:6qig, PDBj:6qig
PDBsum6qig
PubMed31439947
UniProtQ76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (Gene Name=ADAMTS13)

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