Structure of PDB 6pek Chain A Binding Site BS04

Receptor Information
>6pek Chain A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR
APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL
VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGV
DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS
PLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEM
RNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6pek Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6pek Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		T389 D441
Binding residue
(residue number reindexed from 1)		T67 D119
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6pek, PDBe:6pek, PDBj:6pek
PDBsum6pek
PubMed31767681
UniProtQ9UBP0|SPAST_HUMAN Spastin (Gene Name=SPAST)

[Back to BioLiP]