Structure of PDB 6oes Chain A Binding Site BS04

Receptor Information
>6oes Chain A (length=548) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEKVL
LPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPVDTIAKRFRYD
SALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCDGMGDVSEKHG
SGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEPKPNSELCCKPLCLMLA
DESDHETLTAILSPLIAEREAMKSSELTLEMGGIPRTFKFIFRGTGYDEK
LVREVEGLEASGSVYICTLCDTTRLEASQNLVFHSITRSHAENLQRYEVW
RSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIFQL
EIGEVYKHPNASKEERKRWQATLDKHLRKRMNLKPIMRMNGNFARKLMTQ
ETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQYS
FNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEG
NQSGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6oes How mouse RAG recombinase avoids DNA transposition.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		K645 S648 E649 R855 P891 R894 S895 E901 E959
Binding residue
(residue number reindexed from 1)		K185 S188 E189 R395 P431 R434 S435 E441 E499
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0008542 visual learning
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0043029 T cell homeostasis
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0070233 negative regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:2000822 regulation of behavioral fear response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oes, PDBe:6oes, PDBj:6oes
PDBsum6oes
PubMed32015553
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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