Structure of PDB 6mpx Chain A Binding Site BS04

Receptor Information
>6mpx Chain A (length=673) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSC
LRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRP
FISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEG
SGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFK
KPTPSTLKAGELRTHVSRCQVCMGTGYLLVKHSQTDQEPMCPVGMNKLWS
GYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDK
SYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCP
AGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRG
TCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHISRCQVCMAPGF
LVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRK
FSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFIS
RCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQ
ALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPT
PSTLKAGELRTHVSRCQVCMRRT
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain6mpx Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mpx A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		A74 R76
Binding residue
(residue number reindexed from 1)		A71 R73
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005201 extracellular matrix structural constituent
Cellular Component
GO:0005581 collagen trimer

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6mpx, PDBe:6mpx, PDBj:6mpx
PDBsum6mpx
PubMed30923125
UniProtP02462;
P08572

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