Structure of PDB 6m0x Chain A Binding Site BS04

Receptor Information
>6m0x Chain A (length=1032) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQGR
RLARRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSNE
ELFIALKNMVKHRGISYKTPGQIQLERYQTYGQLRGDFTVEKDGKKHRLI
NVFPTSAYRSEALRILQTQQEFNPQITDEFINRYLEILTGKRKYYHGPGN
EKSRTDYGRYRTSGETLDNIFGILIGKCTFYPDEFRAAKASYTAQEFNLL
NDLNNLTVPTKLSKEQKNQIINYVKNEKAMGPAKLFKYIAKLLDVADIKG
YRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETLDKLAYVLTLNTERE
GIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGKGWHNFSVKLMMELI
PELYETSEEQMTILTRLGYIDEKLLTEEIYNPVVAKSVRQAIKIVNAAIK
EYGDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKAANQYNGK
AELPHSVFHGHKQLATKIRLWHQQGERCLYTGKTISIHDLINNSNQFEVD
AILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAWSFRELKA
FVRESKTLSNKKKEYLLTEEDISKFDVIERNLVDTRYASRVVLNALQEHF
RAHKIDTKVSVVRGQFTSQLRRHWGIEKTRDTYHHHAVDALIIAASSQLN
LPYQHFVDTLKSKEFEDSILFSYQVDSKFNRKISDATIYATRQAKVGKDK
ADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFEKVIEPI
LENYPNKQINEKGKEVPCNPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYD
SKLGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKYADLQ
FEKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQ
QLFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGL
GKSNISIYKVRTDVLGNQHIIKNEGDKPKLDF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6m0x Chain A Residue 1207 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m0x Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Resolution2.561 Å
Binding residue
(original residue number in PDB)		D598 N622
Binding residue
(residue number reindexed from 1)		D550 N574
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6m0x, PDBe:6m0x, PDBj:6m0x
PDBsum6m0x
PubMed
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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