Structure of PDB 6lxe Chain A Binding Site BS04

Receptor Information
>6lxe Chain A (length=768) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAK
AIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYP
GEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEG
FSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLF
RDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQIL
LYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVR
IDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHL
LANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIR
SDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHH
LNFGMNPDHARNSLSNCGIRQPINHNERLEFLGDAVVEFLTSVHLYYLFP
SLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHA
MANCFQALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ
EPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLT
LGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAK
VAEELGMQEYAITNDKTKRPVALRTKTLADLLQSFIAALYIDKDLEYVHT
FMNVCFFPRLKEFILNQD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6lxe Chain A Residue 1402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lxe Structural Basis for pri-miRNA Recognition by Drosha.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		C536 H549 H1026
Binding residue
(residue number reindexed from 1)		C83 H96 H537
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6lxe, PDBe:6lxe, PDBj:6lxe
PDBsum6lxe
PubMed32220645
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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