Structure of PDB 6ld3 Chain A Binding Site BS04

Receptor Information
>6ld3 Chain A (length=578) Species: 2043570 (Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNMKIIGNRIERIRSEHAETWFFDENHPYRTWAYHGSYEAPSLINGVVRL
LSKPWDVVTGVTGIAPYGQQRVFKEKVDTRVPDPQEGTRQVMSMVSSWLW
KELGKHKRPRVCTKEEFINKVRSNTAVEAVNDPRFWALVDKEREHHLRGE
CQSCVYNMMGKRSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVE
GLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQME
KGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTY
ALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKR
MAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVP
FCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKS
YAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGEWMTTE
DMLVVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRT
TWAENIKNTVNMVRRIIGDEEKYMDYLS
Ligand information
Ligand IDFB2
InChIInChI=1S/C6H7NO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
InChIKeyKHBQMWCZKVMBLN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.6.1c1ccc(cc1)S(=O)(=O)N
CACTVS 3.352N[S](=O)(=O)c1ccccc1
ACDLabs 10.04O=S(=O)(N)c1ccccc1
FormulaC6 H7 N O2 S
Namebenzenesulfonamide
ChEMBLCHEMBL27601
DrugBank
ZINCZINC000000330150
PDB chain6ld3 Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ld3 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		R739 T796 W797
Binding residue
(residue number reindexed from 1)		R430 T487 W488
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6ld3, PDBe:6ld3, PDBj:6ld3
PDBsum6ld3
PubMed32796069
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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