Structure of PDB 6k32 Chain A Binding Site BS04

Receptor Information
>6k32 Chain A (length=1208) Species: 205895 (Cypovirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKLHNTIFSETRKFTRESFKEIEHLTARLANDRVARHDFLFNTSIVLISD
YSGEDSNGNQLQATITIPNEIINPKEYDPSDYPLAEDESFFKQGHKYDYL
VTFRAGSLTNTYEPKTKMYKLHAALDKLMHVKQRKSRFADLWRELCAVIA
SLDVWYQTTNYPLRTYVKLLFHKGDEFPFYESPSQDRIIFNDKSVASILP
TFVYTCCQVGTAIMSGILTHVESIVAMNHFLHCAKDSYIDEKLKIKGIGR
SWYQEALHNVCQATVPVWSQFNEVIGHRTKSTSEPHFVSSTFISLRAKRA
ELLYPEFNAYINRAIQLSKTQNDVANYYAACRAMTNDGTFLATLTELSLD
AAVFPRIEQHLVTRPAVLMSNTRHESLKQKYTNGVGSIAQSYLSSFTDEI
AKRVNGRHHDEAWLNFLTTSSPGRKLTEIEKLEVGGDVAAWSNSRIVMQA
VFAREYRTPERIFKSLKAPIKLVERQQSDRRQRAISGLDNDRLFLSFMPY
TIGKQIYELNDNAAQGKQAGNAFDIGEMLYWTSQRNVLLSSIDVAGMDAS
VTTNTKDIYNTFVLDVASKCTVPRFGPYYAKNMEVFEAGNRQSQVRYVNA
AWQACALEAANSQTSTSYESEIFGQVKNAEGTYPSGRADTSTHHTVLLQG
LVRGNELKRASDGKNSCLATIKILGDDIMEIFQGSESDTYDHAVSNASIL
NESGFATTAELSQNSIVLLQQLVVNGTFWGFADRISLWTREDTKDIGRLN
LAMMELNALIDDLVFRVRRPEGLKMLGFFCGAICLRRFTLSVDNKLYDST
YNNLSKYMTLTKYDKNPDSDSTLMSLILPLAWLFMPRGGEYPAYPFERRD
GTFTEDESMFTARGAYKRRLLYDVSNIGEMIQQNSMALDDDLLHEYGFTG
ALLLIDLNILDLIDEVKKEDISPVKVSELATSLEQLGKLGEREKSRRAAS
DLKIRGHALSNDIVYGYGLQEKIQKSAMATKETTVQSKRVSSRLHDVIVA
KTRDYKISTIPADALHLHEFEVEDVTVDLLPHAKHTSYSSLAYNMSFGSD
GWFAFALLGGLDRSANLLRLDVASIRGNYHKFSYDDPVFKQGYKIYKSDA
TLLNDFFTAISAGPKEQGILLRAFAYYSLYGNVEYHYVLSPRQLFFLSDN
PVSAERLVRIPPKYYVSTQCRALYNIFSYLHILRSIANNRGKRLKMVLHP
GLIAYVRG
Ligand information
Ligand IDMG7
InChIInChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1
InChIKeyOGHAROSJZRTIOK-KQYNXXCUSA-O
SMILES
SoftwareSMILES
CACTVS 3.341C[n+]1cn([CH]2O[CH](CO)[CH](O)[CH]2O)c3N=C(N)NC(=O)c13
CACTVS 3.341C[n+]1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c3N=C(N)NC(=O)c13
OpenEye OEToolkits 1.5.0C[n+]1cn(c2c1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
ACDLabs 10.04O=C1c2[n+](cn(c2N=C(N)N1)C3OC(C(O)C3O)CO)C
OpenEye OEToolkits 1.5.0C[n+]1cn(c2c1C(=O)NC(=N2)N)C3C(C(C(O3)CO)O)O
FormulaC11 H16 N5 O5
Name7-METHYLGUANOSINE
ChEMBLCHEMBL1234293
DrugBankDB03493
ZINCZINC000018130229
PDB chain6k32 Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6k32 Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R37 Y184 S186 S188
Binding residue
(residue number reindexed from 1)		R33 Y180 S182 S184
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6k32, PDBe:6k32, PDBj:6k32
PDBsum6k32
PubMed31629769
UniProtD0EZK6

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