Structure of PDB 6inq Chain A Binding Site BS04

Receptor Information
>6inq Chain A (length=1405) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKHI
SPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTH
KLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQA
LQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQV
GVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRID
LRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMP
YSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSP
QSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPA
ILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMF
GVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSI
GIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESF
EGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSAC
VGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFF
FHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDII
QFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIE
YAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRI
IQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQN
ATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEM
VGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIAL
DIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQ
SPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLII
RCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYK
NEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLY
KEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMR
CSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKL
LTSLP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6inq Chain A Residue 1801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6inq Structural basis of the nucleosome transition during RNA polymerase II passage.
Resolution6.9 Å
Binding residue
(original residue number in PDB)		C70 C77 H80
Binding residue
(residue number reindexed from 1)		C69 C76 H79
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6inq, PDBe:6inq, PDBj:6inq
PDBsum6inq
PubMed30287617
UniProtC4R4Y0

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