Structure of PDB 6glc Chain A Binding Site BS04

Receptor Information
>6glc Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PMIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKE
LRNDWTVQNCDLDQQSIVHIVQRQSLTRVDLSYNSFYVYCKGPCQRVQPG
KLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFF
KCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVIC
LDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEE
QYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDCRKVTCENGLGCGF
AFCRECKEAYHEGECS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6glc Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6glc Mechanism of parkin activation by PINK1.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C238 C241 C260 C263
Binding residue
(residue number reindexed from 1)		C178 C181 C200 C203
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6glc, PDBe:6glc, PDBj:6glc
PDBsum6glc
PubMed29995846
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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