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Receptor Information

>6fhh Chain A (length=709) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMGS
GSGENLYFQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6fhh Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
Resolution	2.7 Å
Binding residue (original residue number in PDB)	A287 M288 K289 L290 S291 T313 R449 M543 E544 I545 R546 K554
Binding residue (residue number reindexed from 1)	A272 M273 K274 L275 S276 T298 R434 M528 E529 I530 R531 K539

Enzyme Commision number

	Molecular Function
GO:0003723	RNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting

PDB	RCSB:6fhh, PDBe:6fhh, PDBj:6fhh
PDBsum	6fhh
PubMed
UniProt	H6QM92

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Structure of PDB 6fhh Chain A Binding Site BS04