Structure of PDB 6eu1 Chain A Binding Site BS04

Receptor Information
>6eu1 Chain A (length=1433) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLA
HNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETY
IWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKG
ISINNMMEHWDYLQLTVAMYINSDSVNPGGKVKPIRGFCQRLKGKQGRFR
GNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHK
LQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERH
LEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGD
EMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLIS
HKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIK
PNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMD
KSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGIN
DVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAK
IGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQ
QIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHA
ISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFT
YGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANE
ILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGK
ATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEK
SVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHASMNV
TLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDV
AFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQA
SDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRMQQLRRALPD
VVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHV
LEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVL
GITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQ
TMSIGTGSFKVVKGTNISEKDLVPKRCLFESLS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6eu1 Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eu1 Structural basis of RNA polymerase III transcription initiation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D511 D513 D515
Binding residue
(residue number reindexed from 1)		D496 D498 D500
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6eu1, PDBe:6eu1, PDBj:6eu1
PDBsum6eu1
PubMed29345637
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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