Structure of PDB 6a5n Chain A Binding Site BS04

Receptor Information
>6a5n Chain A (length=502) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDSSRNKVKETLRLFHGVCRKILQEDEAKPEDQRRKGKGLRIDFEASTIL
KRNGKFLNSGVHILGEVPGVEVGDEFQYRMELNILGIHKPSQAGIDYMKY
GKAKVATSIVASGGYDDHLDNSDVLTYTGQGGNPEDQKLITGNLALATSI
EKQTPVRVIRGKHKSTHDKSKGGNYVYDGLYLVEKYWQQVGSHGMNVFKF
QLRRIPGQPELSWVEVKKSKSKYREGLCKLDISEGKEQSPISAVNEIDDE
KPPLFTYTVKLIYPDWCRPVPPKSCCCTTRCTEAEARVCACVEKNGGEIP
YNFDGAIVGAKPTIYECGPLCKCPSSCYLRVTQHGIKLPLEIFKTKSRGW
GVRCLKSIPIGSFICEYVGELLEDSEAERRIGNDEYLFDIGNRYDNSLAQ
GMSELMLGTQAGRSMAEGDESSGFTIDAASKGNVGRFINHSCSPNLYAQN
VLYDHEDSRIPHVMFFAQDNIPPLQELCYDYNYALDQVRDSKGNIKQKLC
FC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6a5n Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6a5n Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C559 C595 C601
Binding residue
(residue number reindexed from 1)		C281 C317 C323
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6a5n, PDBe:6a5n, PDBj:6a5n
PDBsum6a5n
PubMed30150382
UniProtQ8VZ17|SUVH6_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 (Gene Name=SUVH6)

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