Structure of PDB 5yew Chain A Binding Site BS04

Receptor Information

>5yew Chain A (length=390) Species: 9606 (Homo sapiens)

VSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDL
VEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSG
IGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKVNNQLAHALHMDKDLKA
GCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVL
VANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRR
QHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAALAEGFHA
RLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAA
EDLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5yew Chain A Residue 804

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): S89 T109 D178
• Binding residue (residue number reindexed from 1): S85 T105 D174
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0008053 mitochondrial fusion

Cellular Component

• GO:0005741 mitochondrial outer membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5yew, PDBe:5yew, PDBj:5yew
• PDBsum: 5yew
• PubMed: 29483649
• UniProt: Q8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)