Structure of PDB 5xxz Chain A Binding Site BS04

Receptor Information
>5xxz Chain A (length=1334) Species: 1314 (Streptococcus pyogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVS
TAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSSAGMHVTGIVA
GNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESLFIKAIEDAVAL
GADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSD
HDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLMTVEELEKRADL
NHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAQDVKGKIALIERD
PNKYDEMIALAKKHGALGVLIFIPSAFISHEFGKAMSQLNGNGTGSLEFD
SVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGQTGTAMASPQIAGA
SLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQG
AGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLSNKDKTL
RYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVS
QFTKELTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGFKGQFENLAVA
EESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTIS
DNGLHTLGTFKNADGKFILEKNAQGNPVLAISPNGDNNQDFAAFKGVFLR
KYQGLKASVYHASDKEHKNPLWVSPESFKGDKNFNSDIRFAKSTTLLGTA
FSGKSLTGAELPDGYYHYVVSYYPDVVGAKRQEMTFDMILDRQKPVLSQA
TFDPETNRFKPEPLKDRGLAGVRKDSVFYLERKDNKPYTVTINDSYKYVS
VEDNKTFVERQADGSFILPLDKAKLGDFYYMVEDFAGNVAIAKLGDHLPQ
TLGKTPIKLKLTDGNYQTKETLKDNLEMTQSDTGLVTNQAQLAVVHRNQP
QSQLTKMNQDFFISPNEDGNKDFVAFKGLENNVYNDLTVNVYAKDDHQKQ
TPIWSSQAGAGASAIESTAWYGITARGSKVMPGDYQYVVTYRDEHGKEHQ
KQYTISVNDKKPMITQGRFDTINGVDHFTPDKTKALGSSGIVREEVFYLA
KKNGRKFDVTEGKDGITVSDNKVYIPKNPDGSYTISKRDGVTLSDYYYLV
EDRAGNVSFATLRDLKAVGKDKAVVNFGLDLPVPEDKQIVNFTYLVRDAD
GKPIENLEYYNNSGNSLILPYGKYTVELLTYDTNAAKLESDKIVSFTLSA
DNNFQQVTFKMTMLATSQITAHFDHLLPEGSRVSLKTAQGQLIPLEQSLY
VPKAYGKTVQEGTYEVVVSLPPNEVHELSLRLVK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5xxz Chain A Residue 1705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xxz Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
Resolution3.085 Å
Binding residue
(original residue number in PDB)		S1190 N1192 D1194 N1196 D1198
Binding residue
(residue number reindexed from 1)		S964 N966 D968 N970 D972
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xxz, PDBe:5xxz, PDBj:5xxz
PDBsum5xxz
PubMed30049896
UniProtQ3HV58

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