BioLiP

InChI=1S/C8H14N3O12P3S/c9-5-1-2-11(8(12)10-5)6-4-27-7(21-6)3-20-25(16,17)23-26(18,19)22-24(13,14)15/h1-2,6-7H,3-4H2,(H,16,17)(H,18,19)(H2,9,10,12)(H2,13,14,15)/t6-,7+/m0/s1

InChIKey

YLEQMGZZMCJKCN-NKWVEPMBSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.6	C1C(OC(S1)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=CC(=NC2=O)N
CACTVS 3.385	NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)O2
OpenEye OEToolkits 1.7.6	C1[C@H](O[C@H](S1)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=CC(=NC2=O)N
CACTVS 3.385	NC1=NC(=O)N(C=C1)[CH]2CS[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)O2

Formula

C8 H14 N3 O12 P3 S

Name

Lamivudine Triphosphate;
Lamivudine-5'-triphosphate;
3TC Triphosphate;
[[(2R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

PDB chain

5u2s Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Molecular Function

GO:0003677

DNA binding

GO:0003684

damaged DNA binding

GO:0003887

DNA-directed DNA polymerase activity

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO:0005515

protein binding

GO:0008017

microtubule binding

GO:0016779

nucleotidyltransferase activity

GO:0016829

lyase activity

GO:0019899

enzyme binding

GO:0034061

DNA polymerase activity

GO:0046872

metal ion binding

GO:0051575

5'-deoxyribose-5-phosphate lyase activity

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

	Biological Process
GO:0001701	in utero embryonic development
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006287	base-excision repair, gap-filling
GO:0006290	pyrimidine dimer repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006974	DNA damage response
GO:0007435	salivary gland morphogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332	response to gamma radiation
GO:0016445	somatic diversification of immunoglobulins
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045471	response to ethanol
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048872	homeostasis of number of cells
GO:0051402	neuron apoptotic process
GO:0055093	response to hyperoxia
GO:0071707	immunoglobulin heavy chain V-D-J recombination
GO:0071897	DNA biosynthetic process

Biological Process

GO:0001701

in utero embryonic development

GO:0006259

DNA metabolic process

GO:0006260

DNA replication

GO:0006261

DNA-templated DNA replication

GO:0006281

DNA repair

GO:0006284