Structure of PDB 5tsn Chain A Binding Site BS04

Receptor Information
>5tsn Chain A (length=500) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRV
KGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDK
WSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEE
GKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLM
DELKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRA
VLAAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKL
DPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWF
GKLEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPA
FYSKISKLVIAELKEGGFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5tsn Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5tsn Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D242 Y243 D343
Binding residue
(residue number reindexed from 1)		D239 Y240 D340
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tsn, PDBe:5tsn, PDBj:5tsn
PDBsum5tsn
PubMed28383118
UniProtQ70ET3

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