Structure of PDB 5tpk Chain A Binding Site BS04

Receptor Information
>5tpk Chain A (length=202) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFN
NLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVL
DIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPE
VKHLFALHPFTGELSLLRSLDYEASITFLAEAFDIYGTMPPGIATVTVIV
KD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5tpk Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5tpk Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N690 N692 D722 D724 N728 D772
Binding residue
(residue number reindexed from 1)		N1 N3 D33 D35 N39 D83
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tpk, PDBe:5tpk, PDBj:5tpk
PDBsum5tpk
PubMed32963095
UniProtQ99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)

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