Structure of PDB 5tfm Chain A Binding Site BS04

Receptor Information

>5tfm Chain A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDQITYSIVSASAFGSYFD
ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV
FDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIY
SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI
ATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG
TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVT
DCGRPPLKATSSATVFVNLL

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5tfm Chain A Residue 905 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5tfm Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution	2.92 Å
Binding residue (original residue number in PDB)	E659 E714 D747 I748 D750 D783
Binding residue (residue number reindexed from 1)	E121 E176 D209 I210 D212 D245
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:5tfm, PDBe:5tfm, PDBj:5tfm
PDBsum	5tfm
PubMed	30033219
UniProt	Q9H251\|CAD23_HUMAN Cadherin-23 (Gene Name=CDH23)

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