Structure of PDB 5s7s Chain A Binding Site BS04

Receptor Information
>5s7s Chain A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETEL
YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLD
TVSCLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIA
DLGLAVMHSQNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLW
EVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWF
SDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
Ligand information
Ligand ID09V
InChIInChI=1S/C4H8O/c5-3-4-1-2-4/h4-5H,1-3H2
InChIKeyGUDMZGLFZNLYEY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.370		OCC1CC1
OpenEye OEToolkits 1.7.6C1CC1CO
FormulaC4 H8 O
Namecyclopropylmethanol
ChEMBL
DrugBank
ZINCZINC000001760657
PDB chain5s7s Chain A Residue 510 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5s7s XChem group deposition
Resolution1.3 Å
Binding residue
(original residue number in PDB)		M288 K345 K346 G348
Binding residue
(residue number reindexed from 1)		M87 K142 K143 G145
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5s7s, PDBe:5s7s, PDBj:5s7s
PDBsum5s7s
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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