Structure of PDB 5s7n Chain A Binding Site BS04

Receptor Information
>5s7n Chain A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETE
LYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQC
CIADLGLAVMHRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWE
VARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS
DPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
Ligand information
Ligand ID2AI
InChIInChI=1S/C3H5N3/c4-3-5-1-2-6-3/h1-2H,(H3,4,5,6)
InChIKeyDEPDDPLQZYCHOH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cnc([nH]1)N
CACTVS 3.341Nc1[nH]ccn1
ACDLabs 10.04n1ccnc1N
FormulaC3 H5 N3
Name1H-imidazol-2-amine
ChEMBLCHEMBL291627
DrugBank
ZINCZINC000017380534
PDB chain5s7n Chain A Residue 509 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5s7n XChem group deposition
Resolution1.3 Å
Binding residue
(original residue number in PDB)		V359 Y399
Binding residue
(residue number reindexed from 1)		V159 Y186
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5s7n, PDBe:5s7n, PDBj:5s7n
PDBsum5s7n
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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