Structure of PDB 5m3h Chain A Binding Site BS04

Receptor Information
>5m3h Chain A (length=699) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5m3h Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		A287 M288 K289 L290 T313 R449 M543 E544 I545 R546 T547
Binding residue
(residue number reindexed from 1)		A272 M273 K274 L275 T298 R434 M528 E529 I530 R531 T532
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5m3h, PDBe:5m3h, PDBj:5m3h
PDBsum5m3h
PubMed28002402
UniProtH6QM92

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