Structure of PDB 5lwx Chain A Binding Site BS04

Receptor Information
>5lwx Chain A (length=554) Species: 5061 (Aspergillus niger) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSQSPNTPWQGYDINTNYYETIPQTNVVREYWFDIVNTTAALDGVERPVL
LVNGQFPGPTIEANWGDTVKVHVTNRMENNGTAIHFHGIRQLYNNQMDGV
AALTQCPVPPNSSYTYVWRAEEYGSSWYHSHFSLQAWEGVFGGILIHGPS
TAEYDHDLGMVFLNDWSHQTVDEMYQSVLESQNPPHFQTGLINGSNIWVT
ADNQTVGRRFQTEFVPGQRYRLRLVNAAMDTHFRFSIDNHDLTVIASDFV
PIVPFTTNNVPIGMGQRYDIIVTANQAPDNYWIRAIPQSFCSDNANSDNI
KGVLHYEGAADNSDPTSTKWDYGDDIQCLDFSLDELVPWLALDADIGGAQ
MAESDVDFTPFGDVPLYLWTMGGNALNISWKDPTLQQTFEDPDKMDWKAS
QGVIEAAIPNKWTVLVVQTDLPVPHPIHLHGHDFYLLAQGFGQFNPQNVT
LKTHNPPRRDTALMTAATPENGGGGYMVIGFPADNPGVWLIHCHIGFHAT
EGFAQQIVERQSEFNTFFSEDLLENTCDAWDEYAKVNPYGHQYRALAGPY
ESGI
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain5lwx Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lwx Structure and function of Aspergillus niger laccase McoG
Resolution1.49 Å
Binding residue
(original residue number in PDB)		H448 C516 H521
Binding residue
(residue number reindexed from 1)		H425 C493 H498
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H108 H110 H152 H154 H448 H451 H453 H515 C516 H517 I518 H521 F526
Catalytic site (residue number reindexed from 1) H85 H87 H129 H131 H425 H428 H430 H492 C493 H494 I495 H498 F503
Enzyme Commision number 1.10.3.2: laccase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052716 hydroquinone:oxygen oxidoreductase activity
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5lwx, PDBe:5lwx, PDBj:5lwx
PDBsum5lwx
PubMed
UniProtA2QS62

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