Structure of PDB 5jch Chain A Binding Site BS04

Receptor Information
>5jch Chain A (length=661) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKAS
EQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVV
KRYDVIICTAQILENSLLNESVRLSDFSLIIIDQCHHTQKEGVYNNIMRR
YLKEKIKNRKQAKELIPQPQILGLTASPGVGGARSNSKAEEHILKICANL
DACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQK
YCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQI
NDTIRMVDAYNHLNNFYKELKRRKTAESDDSKQDETDEFLMRLFHAKKKQ
LKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHW
IMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLI
ATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSG
SGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMK
AKRDQRKKNPSLITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYH
KRENQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDTKEIFK
KWGELPIIFPD
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain5jch Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5jch Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		R302 Q305 G325 G327 K328 R330
Binding residue
(residue number reindexed from 1)		R5 Q8 G28 G30 K31 R33
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5jch, PDBe:5jch, PDBj:5jch
PDBsum5jch
PubMed27203181
UniProtD9N195

[Back to BioLiP]