Structure of PDB 5iu9 Chain A Binding Site BS04

Receptor Information
>5iu9 Chain A (length=417) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFNLKYTVEEELRAGTKIANVTADAKVAGFAPYLRVISNSEPRWVNLSPA
GLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVNDNAPR
FPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIFGLEI
KTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKV
IDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFI
NFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPA
HCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDS
GANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDS
GYPPLRSSKSFAVKVTD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5iu9 Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5iu9 Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		E117 D174 E176 D210
Binding residue
(residue number reindexed from 1)		E112 D169 E171 D205
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iu9, PDBe:5iu9, PDBj:5iu9
PDBsum5iu9
PubMed27787195
UniProtF8W3X3|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)

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