Structure of PDB 5h8x Chain A Binding Site BS04

Receptor Information

>5h8x Chain A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFT
RISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAE
ETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSL
PQDDIDGIQAIYG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5h8x Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5h8x Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.
Resolution	1.3 Å
Binding residue (original residue number in PDB)	H197 H201 H207
Binding residue (residue number reindexed from 1)	H118 H122 H128
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H197 E198 H201 H207
Catalytic site (residue number reindexed from 1)	H118 E119 H122 H128
Enzyme Commision number	3.4.24.34: neutrophil collagenase.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5h8x, PDBe:5h8x, PDBj:5h8x
PDBsum	5h8x
PubMed	27556138
UniProt	P22894\|MMP8_HUMAN Neutrophil collagenase (Gene Name=MMP8)

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