Structure of PDB 5h0u Chain A Binding Site BS04

Receptor Information

>5h0u Chain A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYA
YIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHF
DSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMD
TENFVLPDDDRRGIQQLYGG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5h0u Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5h0u Solvent water interactions within the active site of the membrane type I matrix metalloproteinase.
Resolution	2.239 Å
Binding residue (original residue number in PDB)	H186 D188 H201 H214
Binding residue (residue number reindexed from 1)	H71 D73 H86 H99
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H239 E240 H243 H249
Catalytic site (residue number reindexed from 1)	H124 E125 H128 H134
Enzyme Commision number	3.4.24.80: membrane-type matrix metalloproteinase-1.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5h0u, PDBe:5h0u, PDBj:5h0u
PDBsum	5h0u
PubMed	28951896
UniProt	P50281\|MMP14_HUMAN Matrix metalloproteinase-14 (Gene Name=MMP14)

[Back to BioLiP]