Structure of PDB 5gz9 Chain A Binding Site BS04

Receptor Information
>5gz9 Chain A (length=280) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHK
VALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPL
GSLSNLEETLQKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSN
DLPKTLSQYLLTSNFSIVANDLDALPLVDSGVLIKCGHRELHGDFVAPEQ
LWPYGEDTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFD
IHKACKSQIPAERPTAQNVLDAYQRVFHSL
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain5gz9 Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5gz9 3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C202 N205 C243 G244 R246
Binding residue
(residue number reindexed from 1)		C147 N150 C186 G187 R189
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.183: glycoprotein-mannosyl O(6)-kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0019200 carbohydrate kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006493 protein O-linked glycosylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5gz9, PDBe:5gz9, PDBj:5gz9
PDBsum5gz9
PubMed28251761
UniProtQ3TUA9|SG196_MOUSE Protein O-mannose kinase (Gene Name=Pomk)

[Back to BioLiP]